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Description. The area under the plasma drug concentration-time curve (AUC) reflects the actual body exposure to drug after administration of a dose of the drug and is expressed in mg*h/L. This area under the curve is dependant on the rate of elimination of the drug from the body and the dose administered. The total amount of drug eliminated by the body may be assessed by adding up or integrating the amounts eliminated in each time interval, from time zero (time of the administration of the If we plot a graph between plasma conc. vs time after oral administration of a drug, then we will get the plasma concentration vs time curve.
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A nonangular continuous bend or line. 2. A chart or graphic representation, by means of a continuous line connecting individual observations, of the course of a physiologic activity, of the number of cases of a disease in a given period, or of any entity that might be otherwise presented by a table of figures. The plasma concentration-time curves of lumefantrine on linear (Figure) and log scale were used to calculate the variety of pharmacokinetic parameters (Table) There was a significant correlation between level of CYP2E1 mRNA in mononuclear cells and the area under the plasma concentration-time curve of plasma inorganic fluoride from the beginning of sevoflurane administration to infinity in uninduced and uninhibited patients (r2 = 0.56; P < 0.01). Results: During itraconazole treatment, or 4 days after, alpha-hydroxymetabolite the dose-corrected area under the plasma midazolam concentration time curve (AUC0-infinity) was 8- or 2.6-fold larger than that before itraconazole (i.e. 1707 or 695 versus 277 ng x h x ml(-1)), respectively.
Repeated administration of trimethoprim/sulfadiazine in the
The area under the plasma concentration–time curve (AUC) increased Area Under the Plasma Concentration-Time Curve From Time Zero to the Last Quantifiable Concentration (AUC 0-t) of Evobrutinib, Pre-dose up to 30 hours Area under the plasma concentration curve (AUC0-∞ ) of 50mg [14C]-SHP626 and RAD extrapolated to infinity, calculated using the observed value of the last Many translated example sentences containing "peak plasma concentration" preferably based on area under the curve (AUC) data, or peak concentration (C then it calculates and draws the plasma concentration curve. The basis for the simulation is a one-compartment model with first-order elimination kinetics. Plasma ketoprofen concentrations were measured by use of high- was calculated for the area under the time-concentration curve (AUC) and maximum area under the plasma concentration versus time curve was 92.5 ng.hr/ml.
Maximum Tolerated Dose and Pharmacokinetics of Paclitaxel
Area under the plasma concentration-time curve † AUC∞ Amount · time/volume Area under the plasma concentration-time curve from timezerotoinfinity AUC t Amount · time/volume Area under the plasma concentration-time curve from time zero to time t Note: AUC 24, not AUC 0–24 or AUC 24h; however, if time periods >24 hours are used, these plasma concentration time curve: Spanish translation: curva de tiempo de concentración de plasma: Entered by: Marcel Ventosa: 02:59 Oct 8, 2004: Area Under plasma concentration-time Curve is abbreviated as AUC. related. The list of abbreviations related to AUC - Area Under plasma concentration-time Curve. The slope of the curve during the absorption phase indicates how quickly the medication reaches peak plasma concentration ("kicks in") after administration. The text seems to imply that the greater this slope, the more addictive a substance is likely to be. The plasma [Fluorine sup -]-time curve after a brief exposure to sevoflurane (0.82 minimum alveolar concentration *symbol* h [MAC *symbol* h]) in infants and children yielded a low peak fluoride value, 13.0+/-3.6 micro Meter, but postoperative measurements were discontinued after only 4 h. 2014-02-05 · ROC curves for blood loss versus fibrinogen concentration and MCF showed that a plasma fibrinogen concentration of 1.5 g l −1 and a MCF value 3 mm or less could be used to predict blood loss.
The graph depicts a typical time course of drug plasma concentration and illustrates main pharmacokinetic metrics
1993-06-03 · plasma concentrations of a drug ; the selection of one or the othe r method of interpretation depends on the needs of the investigator.
17. A third way to recite “plasma concentration-time profile” is to compare the profile of the claimed invention to that of another drug formulation.
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In this video Plasma level time profile curve is explained briefly. The plasma-level time curve for a drug that follows a two-compartment model shows that the plasma drug concentration declines biexponentially as the sum of two first-order processes—distribution and elimination.
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Results: We found a low positive correlation between plasma concentration and dose. A low negative correlation between plasma concentration and increased duration of sleep was noted in the … 2 days ago · Suppose the plasma concentration of the drug is expressed as mg/lit and time in the units of hours. As the Y-axis is plasma concentration of the drug and X-axis is the time interval, area under curve will be multiple of these two parameters with units of mg/lit * hr. If dose, X 0 is expressed in mg then what are the units of K here.